Zinc Supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. Abstract: “BACKGROUND: One of the main problems in the therapy of depression is the limited efficacy of antidepressants and the limited utility of augmentation strategies. Zinc, a non competitive NMDA receptor antagonist exhibits preclinical antidepressant efficacy. Moreover, a preliminary clinical […]
Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. Abstract: BACKGROUND: Theoretically, consumption of complex, multinutrient formulations of vitamins and minerals should be safe, as most preparations contain primarily the nutrients that have been in the human diet for millennia, and at safe levels as defined by the Dietary […]
Psychological burden in the era of HAART: impact of selenium therapy. Abstract: Several different vitamins and minerals appear to be effective augmenting agents for mood-modifying drugs, but are not potent monotherapies in themselves for treating psychiatric disorders. In contrast, broad-spectrum micronutrient interventions appear in early trials to be as effective as psychiatric medications with fewer […]
Oxidative damage and mitochondrial decay in aging. Abstract: We argue for the critical role of oxidative damage in causing the mitochondrial dysfunction of aging. Oxidants generated by mitochondria appear to be the major source of the oxidative lesions that accumulate with age. Several mitochondrial functions decline with age. The contributing factors include the intrinsic rate […]
Association of obesity and inflammatory marker levels on treatment outcome: results from a double-blind, randomized study of adjunctive L-methylfolate calcium in patients with MDD who are inadequate responders to SSRIs. Abstract: “OBJECTIVE: Adjunctive treatment with L-methylfolate calcium significantly improved treatment outcomes in patients with major depressive disorder (MDD) and an inadequate response to antidepressants. This […]
Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind placebo controlled trial. Abstract: “BACKGROUND: Clinical mood disorders often become clinically manifest in the later teenage years and early twenties and can be associated with a poor long-term prognosis. The primary prevention of these disorders would therefore […]
The effect of randomized vitamin-mineral supplementation on violent and non-violent antisocial behavior among incarcerated juveniles. Abstract: In a randomized controlled double-blind trial, the effects of vitamin±mineral supplementation on violence and other serious antisocial behavior were studied for 3 months on 62 con®ned delinquents aged 13 to 17 years. A signi®cant difference between 32 active and […]
The effect of vitamin-mineral supplementation on juvenile delinquency among American schoolchildren: a randomized, double-blind placebo-controlled trial. Abstract: CONTEXT: Numerous studies conducted in juvenile correctional institutions have reported that violence and serious antisocial behavior have been cut almost in half after implementing nutrient- dense diets that are consistent with the World Health Organization’s guidelines for fats, […]
Effect of zinc supplementation on mood states in young women: a pilot study. Abstract: The relation of zinc (Zn) nutriture to brain development and function has been elucidated. The purpose of this study is to examine whether Zn supplementation improves mood states in young women. The study used a double-blind, randomized and placebo-controlled procedure. The […]
Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Abstract: OBJECTIVE: There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants. The adjunctive use of standardized pharmaceutical-grade nutrients, known as nutraceuticals, has the potential to modulate several neurochemical pathways implicated in depression. While many studies have been conducted in this area, to […]