Influence of thiamin supplementation on the health and general well-being of an elderly Irish population with marginal thiamine deficiency. Abstract: The effect of thiamin supplementation on the health and general well-being of 80 randomly selected healthy elderly Irish women, from a population with marginal thiamin deficiency, was studied. Key variables affecting thiamin status were controlled. […]
Research
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment. Abstract: BACKGROUND: Recurrent major depression is associated with decreased blood zinc concentrations that may be increased by effective antidepressant therapy. Some clinical investigations point to alterations of the zinc level in blood as a potential marker of depression. METHODS: A placebo-controlled, double-blind study […]
Zinc Supplementation augments efficacy of imipramine in treatment resistant patients: a double blind, placebo-controlled study. Abstract: “BACKGROUND: One of the main problems in the therapy of depression is the limited efficacy of antidepressants and the limited utility of augmentation strategies. Zinc, a non competitive NMDA receptor antagonist exhibits preclinical antidepressant efficacy. Moreover, a preliminary clinical […]
Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. Abstract: BACKGROUND: Theoretically, consumption of complex, multinutrient formulations of vitamins and minerals should be safe, as most preparations contain primarily the nutrients that have been in the human diet for millennia, and at safe levels as defined by the Dietary […]