Clinically Significant Symptom reduction in children with attention deficit/ hyperactivity disorder treated with micronutrients Abstract: OBJECTIVE: The purpose of this study was to investigate the clinical effect and safety of a broad spectrum, 36 ingredient micronutrient (vitamins and minerals) in treating children with attention-deficit/hyperactivity disorder (ADHD). METHODS: This open-label, on-off-on-off (reversal design) study followed 14 […]
Enhancement of recovery from psychiatric illness by methylfolate Abstract: 41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l) and took part in a double-blind, placebo-controlled trial of methylfolate, 15 mg daily, for 6 months in addition […]
Magnesium oxide augmentation of verapamil maintenance therapy in mania Abstract: The authors compared the antimanic effects of a verapamil-magnesium oxide (V-M) combination with a verapamil-placebo combination (V-P) in patients pretreated with verapamil. BPRS scores and serum magnesium levels were compared. The V-M combination was found to be significantly more effective than V-P in reducing manic […]
Adjuvant thiamine improved standard treatment in patients with major depressive disorder Abstract: Given that antidepressants (ADs) work slowly, there is interest in means to accelerate their therapeutic effect and to reduce side effects. In this regard, thiamine (vitamin B1) is attracting growing interest. Thiamine is an essential nutrient, while thiamine deficiency leads to a broad […]
Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behavior of young adult prisoners Abstract: BACKGROUND: There is evidence that offenders consume diets lacking in essential nutrients and this could adversely affect their behavior. AIMS: To test empirically if physiologically adequate intakes of vitamins, minerals and essential fatty acids cause a reduction […]
Database analysis of adults with bipolar disorder consuming a micronutrient formula Abstract: BACKGROUND: Eleven previous reports have shown potential benefit of a 36-ingredient micronutrient formula (known as EMPowerplus) for the treatment of psychiatric symptoms. The current study asked whether children (7-18 years) with pediatric bipolar disorder (PBD) benefited from this same micronutrient formula; the impact […]
Nutritional and safety outcomes from an open-label micronutrient intervention for pediatric bipolar spectrum disorders Abstract: The purpose of this study was to report the safety, tolerability, and serum micronutrient concentrations and their correlations with mood changes from an 8-week pilot feasibility study of a 36 ingredient multinutrient supplement, EMPowerplus (EMP+), for pediatric bipolar spectrum disorders […]
Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder. Abstract: Early-onset bipolar disorder has significant morbidity and mortality. Development of safe, effective treatments to which patients will adhere is critical. Pharmacologic interventions for childhood bipolar spectrum disorders are limited and are associated with significant risk for adverse events. […]
Effects of nutrients, dietary supplements and vitamins on cognition Abstract: BACKGROUND: Observational studies have suggested that various nutrients, dietary supplements, and vitamins may delay the onset of age-associated cognitive decline and dementia. We systematically reviewed recent randomized controlled trials investigating the effect of nutritional interventions on cognitive performance in older non-demented adults. METHODS: We searched MEDLINE, […]
Adequacy or deprivation of dietary selenium in healthy men Abstract: Thirty healthy young men were fed diets that provided either 32.6 or 226.5 μg of selenium (Se)/d for 105 d. The high Se diet significantly elevated plasma Se and platelet glutathione peroxidase activity. Selenium balance of subjects consuming the high Se diet was >100 μg/d, […]