Micronutrients Research

The impact of selenium supplementation on mood Biol Psychiatry 29 Large Image

Effectiveness of chromium in atypical depression


BACKGROUND: Chromium picolinate (CP) has been reported to benefit patients with symptoms of atypical depression.

METHODS: A placebo-controlled, double-blind, pilot study of CP was conducted in 15 patients with DSM-IV major depressive disorder, atypical type. Patients received 600 μg of CP or matching placebo (PBO) for 8 weeks.

RESULTS: Seven (70%) CP and zero (0%) PBO patients met responder criteria (p = .02). Other outcomes were consistent with greater effect of CP. Three patients on CP failed to show any improvement. Chromium picolinate was well tolerated.

CONCLUSIONS: Chromium picolinate shows promising antidepressant effects in atypical depression. Its mechanism of action may relate to 5HT2A downregulation, increased insulin sensitivity, or to other effects.

Placebo-controlled trial

Davidson JR, Abraham K, Conner KM, McLeod MN:

Biol Psychiatry 53(3):261-264, 2003 12559660


Your email address will not be published. Required fields are marked *