Vitamin B12 supplementation in treating major depressive disorder: a randomized controlled trial.
“BACKGROUND/ OBJECTIVE: Recent literature has identified links between vitamin B12 deficiency and depression. We compared the clinical response of SSRI-monotherapy with that of B12-augmentation in a sample of depressed patients with low normal B12 levels who responded inadequately to the first trial with the SSRIs. METHODS: Patients with depression and low normal B12 levels were randomized to a control arm (antidepressant only) or treatment arm (antidepressants and injectable vitamin B12 supplementation). RESULTS: A total of 199 depressed patients were screened. Out of 73 patients with low normal B12 levels 34 (47%) were randomized to the treatment group while 39 (53%) were randomized to the control arm. At three months follow up 100% of the treatment group showed at least a 20% reduction in HAM-D score, while only 69% in the control arm showed at least a 20% reduction in HAM-D score (p<0.001). The findings remained significant after adjusting for baseline HAM-D score (p=0.001). CONCLUSION: Vitamin B12 supplementation with antidepressants significantly improved depressive symptoms in our cohort.”
Syed EU, Wasay M, Awan S:
Open Neurol J 7:44-48, 2013 24339839